Xanthate based radical cascade toward multicomponent formation of pyrrolopyrimidines.
نویسندگان
چکیده
A short sequential synthesis of pyrrolidino- pyridines and pyrimidines illustrates the potential of combining Ugi-Smiles couplings with radical tin-free processes.
منابع مشابه
Cascade multicomponent synthesis of indoles, pyrazoles, and pyridazinones by functionalization of alkenes.
The development of multicomponent reactions for indole synthesis is demanding and has hardly been explored. The present study describes the development of a novel multicomponent, cascade approach for indole synthesis. Various substituted indole derivatives were obtained from simple reagents, such as unfunctionalized alkenes, diazonium salts, and sodium triflinate, by using an established straig...
متن کاملAn insight into effect of surface functional groups on reactivity of Sphalerite (110) surface with Xanthate collector: a DFT study
The reactivity of the protonated and hydroxylated sphalerite (1 1 0) surface with xanthate was simulated using the density functional theory (DFT). The difference between the energy of the lowest unoccupied molecular orbital of the sphalerite surface and the energy of the highest occupied molecular orbital of xanthate ( was used to compare the reaction capability of xanthate with fresh and fun...
متن کاملThree-component zipper assembly of photoactive cascade architectures with blue, red and colorless naphthalenediimide donors and acceptors.
We report the programmed ("zipper") assembly of photoactive rigid-rod pi-stack architectures composed of blue (b), red (r) and colorless (n) core-substituted naphthalene diimides (NDIs) attached along p-oligophenyl (POP) rods. The design strategy and multistep syntheses of the required NDI-POP conjugates are described first. The activity of the obtained up to three-component cascade architectur...
متن کاملD609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant.
Tricyclodecan-9-yl-xanthogenate (D609) has been extensively studied in biological systems and exhibits a variety of biological functions, including antiviral, antitumor, and anti-inflammatory activities. Most of these activities have been largely attributed to the inhibitory effect of D609 on phosphatidylcholine-specific phospholipase C. However, as a xanthate derivative, D609 is a strong elect...
متن کاملDerivatives of xanthic acid are novel antioxidants: application to synaptosomes.
Xanthic acids have long been known to act as reducing agents. Recently, D609, a tricyclodecanol derivative of xanthic acid, has been reported to have anti-apoptotic and anti-inflammatory properties that are attributed to specific inhibition of phosphatidyl choline phospholipase C (PC-PLC). However, because oxidative stress is involved in both of these cellular responses, the possibility that xa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 16 11 شماره
صفحات -
تاریخ انتشار 2011